Article
Chromosomal changes in colorectal adenomas: relationship to gene mutations and potential for clinical utility.
Genes, chromosomes & cancer - 1 Feb 2006
Leslie Amy, Stewart Arlene, Baty David U, Mechan Dorothy, McGreavey Louise, Smith Gillian, Wolf C Roland, Sales Mark, Pratt Norman R, Steele Robert J C, Carey Francis A
Abstract excerpt
Although the occurrence of both chromosomal aberrations and specific gene mutations in colorectal tumorigenesis is firmly established, the relationship between these different forms of genetic abnormality remains poorly understood. We have previously demonstrated, in colorectal adenocarcinomas, that mutations of APC, KRAS, and TP53 are each specifically associated with certain chromosomal aberrations. Using...
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