Article
Cytochrome oxidase deficiency in Alzheimer's disease.
Annals of the New York Academy of Sciences - 1 Jan 1991
Parker W D
Abstract excerpt
Alzheimer's disease (AD) is a degenerative neurologic disorder that may be familial but is usually sporadic and not easily analyzable in terms of conventional Mendelian genetics. The mitochondrial electron transport chain contains 13 proteins that are encoded by mitochondrial genes rather than nuclear (chromosomal) genes. Disorders resulting from heteroplasmic mutations of mitochondrial genes may appear to be...
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