Mutations in mitochondrial‐encoded cytochrome <b><i>c</i></b> oxidase subunits I, II, and III genes detected in Alzheimer's disease using single‐strand conformation polymorphism

Abstract excerpt

A "mitochondrial hypothesis" of late onset Alzheimer's disease (AD) has been proposed. Biochemical studies indicate that there is a significant decrease in cytochrome oxidase (CO) activity as well as perturbed CO I and CO III mRNA levels in platelets and brain tissue from Alzheimer's patients. Using the electrophoretic mutation detection technique SSCP and DNA sequencing, we have identified 20 point mutations in...

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