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Clinical features and pathogenesis of Alzheimer's disease: involvement of mitochondria and mitochondrial DNA.

Advances in experimental medicine and biology - 1 Jan 2010

Mancuso Michelangelo, Orsucci Daniele, LoGerfo Annalisa, Calsolaro Valeria, Siciliano Gabriele

Abstract excerpt

Alzheimer's disease (AD) is a neurodegenerative disorder which results in the irreversible loss of cortical neurons, particularly in the associative neocortex and hippocampus. AD is the most common form of dementia in the elderly people. Apart from the neuronal loss, the pathological hallmarks are extracellular senile plaques containing the peptide beta-amyloid (AP) and neurofibrillary tangles. The Af cascade...

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PMID: 20687493
DOI: 10.1007/978-1-4419-6448-9_4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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