Cybrids in Alzheimer's disease: a cellular model of the disease?

doi:10.1212/wnl.49.4.918

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Article

Cybrids in Alzheimer's disease: a cellular model of the disease?

Neurology - 1 Oct 1997

Swerdlow R H, Parks J K, Cassarino D S, Maguire D J, Maguire R S, Bennett J P, Davis R E, Parker W D

Abstract excerpt

The mitochondrial electron transport chain enzyme cytochrome c oxidase (COX) is defective in patients with sporadic Alzheimer's disease (AD). This defect arises from the mutation of mitochondrial DNA (mtDNA). To develop a tissue culture system that would express this genetically derived bioenerge...

Topics

Alzheimer Disease
Brain
Cytoplasm
DNA, Mitochondrial
Electron Transport Complex IV
Gene Transfer Techniques
Genetic Techniques
Humans
Hybridization, Genetic
Mutation
Reactive Oxygen Species
Reference Values
Teratocarcinoma
Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 9339668
DOI: 10.1212/wnl.49.4.918

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9339668-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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