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Article

Cybrids in Alzheimer's disease: a cellular model of the disease?

Neurology - 1 Oct 1997

Swerdlow R H, Parks J K, Cassarino D S, Maguire D J, Maguire R S, Bennett J P, Davis R E, Parker W D

Abstract excerpt

The mitochondrial electron transport chain enzyme cytochrome c oxidase (COX) is defective in patients with sporadic Alzheimer's disease (AD). This defect arises from the mutation of mitochondrial DNA (mtDNA). To develop a tissue culture system that would express this genetically derived bioenergetic lesion and permit characterization of its functional consequences, we depleted Ntera2/D1 (NT2) teratocarcinoma...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 9339668
DOI: 10.1212/wnl.49.4.918

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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