Article
Mitochondrial involvement in Alzheimer's disease.
Biochimica et biophysica acta - 9 Feb 1999
Bonilla E, Tanji K, Hirano M, Vu T H, DiMauro S, Schon E A
Abstract excerpt
The causes of most neurodegenerative diseases, including sporadic Alzheimer's disease (AD), remain enigmatic. There is, however, increasing evidence implicating mitochondrial dysfunction resulting from deafferentiation of disconnected neural circuits in the pathogenesis of energy deficit in AD. The patterns of reduced expression of both mitochondrial DNA (mtDNA) and nuclear DNA (nDNA) encoded genes is consistent...
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