Article
The RET receptor: function in development and dysfunction in congenital malformation.
Trends in genetics : TIG - 1 Oct 2001
Manié S, Santoro M, Fusco A, Billaud M
Abstract excerpt
Germline mutations in the RET proto-oncogene are responsible for two unrelated neural crest disorders: Hirschsprung disease, a congenital absence of the enteric nervous system in the hindgut, and multiple endocrine neoplasia type 2, a dominantly inherited cancer syndrome. Moreover, somatic rearrangements of RET are causally involved in the genesis of papillary thyroid carcinoma. The receptor tyrosine kinase...
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