Article
The C-terminus of complement regulator Factor H mediates target recognition: evidence for a compact conformation of the native protein.
Clinical and experimental immunology - 1 May 2006
Oppermann M, Manuelian T, Józsi M, Brandt E, Jokiranta T S, Heinen S, Meri S, Skerka C, Götze O, Zipfel P F
Abstract excerpt
The complement inhibitor Factor H has three distinct binding sites for C3b and for heparin, but in solution uses specifically the most C-terminal domain, i.e. short consensus repeats (SCR) 20 for ligand interaction. Two novel monoclonal antibodies (mABs C14 and C18) that bind to the most C-terminal domain SCR 20 completely blocked interaction of Factor H with the ligands C3b, C3d, heparin and binding to...
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