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Article

Factor H and atypical hemolytic uremic syndrome: mutations in the C-terminus cause structural changes and defective recognition functions.

Journal of the American Society of Nephrology : JASN - 1 Jan 2006

Józsi Mihály, Heinen Stefan, Hartmann Andrea, Ostrowicz Clemens W, Hälbich Steffi, Richter Heiko, Kunert Anja, Licht Christoph, Saunders Rebecca E, Perkins Stephen J, Zipfel Peter F, Skerka Christine

Abstract excerpt

Atypical hemolytic uremic syndrome is a disease that is characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure. Mutations in the complement regulator factor H are associated with the inherited form of the disease, and >60% of the mutations are located within the C terminus of factor H. The C-terminus of factor H, represented by short consensus repeat 19 (SCR19) and SCR20,...

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Identifiers

PMID: 16338962
DOI: 10.1681/ASN.2005080868

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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