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Article

Dual interaction of factor H with C3d and glycosaminoglycans in host–nonhost discrimination by complement

1 Feb 2011

Abstract excerpt

The alternative pathway of complement is important in innate immunity, attacking not only microbes but all unprotected biological surfaces through powerful amplification. It is unresolved how host and nonhost surfaces are distinguished at the molecular level, but key components are domains 19-20 of the complement regulator factor H (FH), which interact with host (i.e., nonactivator surface glycosaminoglycans or...

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PMID: 21285368
DOI: 10.1073/pnas.1017087108

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