Identification of complement regulatory domains in human factor H.

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Article

Identification of complement regulatory domains in human factor H.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 1995

Gordon D L, Kaufman R M, Blackmore T K, Kwong J, Lublin D M

Abstract excerpt

Factor H, a regulator of complement activation, contains 20 short consensus repeat (SCR) domains common among the family of C3b/C4b-binding proteins. Chinese hamster ovary cells transfected with cDNA corresponding to the N-terminal tryptic fragment of factor H (containing SCR 1-5 and part of SCR 6) secreted protein with cofactor activity for factor I-dependent cleavage of C3b. A series of deletion mutants, each...

Topics

Animals
Antigens, CD
Blotting, Western
CD55 Antigens
CHO Cells
Complement Factor H
Complement Inactivator Proteins
Cricetinae
Cytotoxicity Tests, Immunologic
Cytotoxicity, Immunologic
DNA, Complementary

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Membrane Glycoproteins

Mutation

Phosphatidylinositols

Recombinant Fusion Proteins

Repetitive Sequences, Nucleic Acid

Transfection

Source

Open in PubMed

Identifiers

PMID: 7541419

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7541419-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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