Article
Lack of TP53 and FMS gene mutations in children with myelodysplastic syndrome.
Cancer genetics and cytogenetics - 15 Apr 2006
Jekic Biljana, Novakovic Ivana, Lukovic Ljiljana, Kuzmanovic Milos, Popovic Branka, Milasin Jelena, Bunjevacki Gordana, Damnjanovic Tatjana, Cvjeticanin Suzana, Bunjevacki Vera
Abstract excerpt
Myelodysplastic syndromes (MDS) are rare disorders in children. Molecular mechanisms underlying MDS in children are not yet completely understood. Considering the role of FMS and TP53 gene mutations in adult MDS patients, we analyzed mutations of these genes in a cohort of 35 children with MDS. Single-strand conformation polymorphism polymerase chain reaction analysis performed on FMS codon 969 and TP53 exons 5-9...
Topics
- Child, Preschool
- Codon
- Cohort Studies
- DNA Mutational Analysis
- DNA, Neoplasm
- Exons
- Genes, fms
- Genes, p53
- Humans
- Mutation
- Myelodysplastic Syndromes