Article
Two new polymorphisms but no mutations of the KIT gene in patients with myelodysplasia at positions corresponding to human FMS and murine W locus mutational hot spots.
Leukemia - 1 Nov 1993
Bowen D T, Padua R A, Burnett A K, deCastro C M, Kaufman R E
Abstract excerpt
The KIT proto-oncogene encodes a tyrosine kinase receptor which plays a critical role in haemopoiesis. We have screened genomic DNA from bone marrow mononuclear cells of 46 patients with myelodysplasia (MDS) for mutations/deletions of exons 6, 13, 17, and 21 of the KIT gene (stem cell factor rece...
Topics
- Animals
- Base Sequence
- Chromosome Mapping
- Exons
- Genes, fms
- Humans
- Mice
- Molecular Sequence Data
- Mutation
- Myelodysplastic Syndromes
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Proto-Oncogene Mas
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-kit
- Proto-Oncogenes
- Receptor Protein-Tyrosine Kinases
- Receptors, Colony-Stimulating Factor