Article
Two new polymorphisms but no mutations of the KIT gene in patients with myelodysplasia at positions corresponding to human FMS and murine W locus mutational hot spots.
Leukemia - 1 Nov 1993
Bowen D T, Padua R A, Burnett A K, deCastro C M, Kaufman R E
Abstract excerpt
The KIT proto-oncogene encodes a tyrosine kinase receptor which plays a critical role in haemopoiesis. We have screened genomic DNA from bone marrow mononuclear cells of 46 patients with myelodysplasia (MDS) for mutations/deletions of exons 6, 13, 17, and 21 of the KIT gene (stem cell factor receptor) using polymerase chain reaction (PCR), polyacrylamide gel electrophoresis, and autoradiography to detect...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.