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Article

Yin Yang 1 physically interacts with Hoxa11 and represses Hoxa11-dependent transcription.

The Journal of biological chemistry - 3 Nov 2006

Luke Margaret Po-shan, Sui Guangchao, Liu Huifei, Shi Yang

Abstract excerpt

Yin Yang 1 (YY1) plays an indispensable role in embryonic development. YY1 contains an evolutionarily conserved, 22-amino acid segment, the PHO homology region (PHR), which is located within its central domain (spacer) and has been shown previously to participate in the recruitment of Polycomb group of proteins and in YY1-mediated transcription. In this report, we show that the PHR physically interacts with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16963455
DOI: 10.1074/jbc.M606584200

Genes

HDAC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Yin Yang 1 physically interacts with Hoxa11 and represses Hoxa11-dependent transcription.PMID 16963455Read ↗

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YY1 DNA binding and interaction with YAF2 is essential for Polycomb recruitment.Semantic proximity Read ↗

The polycomb group protein EED interacts with YY1, and both proteins induce neural tissue in Xenopus embryos.Semantic proximity Read ↗

YY1 DNA binding and PcG recruitment requires CtBP.Semantic proximity Read ↗

Cooption of polyalanine tract into a repressor domain in the mammalian transcription factor HoxA11Semantic proximity Read ↗

The Drosophila RYBP gene functions as a Polycomb-dependent transcriptional repressor.Semantic proximity Read ↗

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