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Article

YY1 DNA binding and interaction with YAF2 is essential for Polycomb recruitment.

Nucleic acids research - 1 Feb 2014

Basu Arindam, Wilkinson Frank H, Colavita Kristen, Fennelly Colin, Atchison Michael L

Abstract excerpt

Polycomb Group (PcG) proteins are crucial for epigenetic inheritance of cell identity and are functionally conserved from Drosophila to humans. PcG proteins regulate expression of homeotic genes and are essential for axial body patterning during development. Earlier we showed that transcription factor YY1 functions as a PcG protein. YY1 also physically interacts with YAF2, a homolog of RYBP. Here we characterize...

Topics

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Chromatin
Drosophila
Gene Silencing
HeLa Cells
Muscle Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polycomb Repressive Complex 1

Protein Interaction Domains and Motifs

YY1 Transcription Factor

Source

Open in PubMed Open full text

Identifiers

PMID: 24285299
DOI: 10.1093/nar/gkt1187
PMCID: PMC3936737

Genes

YAF2
RYBP
PRC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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YY1 DNA binding and interaction with YAF2 is essential for Polycomb recruitment.PMID 24285299Read ↗

YY1 DNA binding and PcG recruitment requires CtBP.Semantic proximity Read ↗

Homeotic transformations of the axial skeleton of YY1 mutant mice and genetic interaction with the Polycomb group gene Ring1/Ring1A.Semantic proximity Read ↗

Transcription factor YY1 functions as a PcG protein in vivo.Semantic proximity Read ↗

The Drosophila RYBP gene functions as a Polycomb-dependent transcriptional repressor.Semantic proximity Read ↗

Yin Yang 1 physically interacts with Hoxa11 and represses Hoxa11-dependent transcription.Semantic proximity Read ↗

YEAF1/RYBP and YAF-2 are functionally distinct members of a cofactor family for the YY1 and E4TF1/hGABP transcription factors.Semantic proximity Read ↗

Jarid2 Methylation via the PRC2 Complex Regulates H3K27me3 Deposition during Cell Differentiation.Semantic proximity Read ↗

Functional analysis of AEBP2, a PRC2 Polycomb protein, reveals a Trithorax phenotype in embryonic development and in ESCs.Semantic proximity Read ↗

Juxtaposed Polycomb complexes co-regulate vertebral identity.Semantic proximity Read ↗

dRYBP counteracts chromatin-dependent activation and repression of transcription.Semantic proximity Read ↗

The Pygo2-H3K4me2/3 interaction is dispensable for mouse development and Wnt signaling-dependent transcription.Semantic proximity Read ↗

De novo variants in RYBP are associated with a severe neurodevelopmental disorder and congenital anomalies.Semantic proximity Read ↗

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