Article
Presence of interaction but not complementation between human mtDNAs carrying different mutations within a tRNA(Leu(UUR)) gene.
Biochemical and biophysical research communications - 20 Feb 2004
Ono Tomoko, Kasahara Yoshiko, Nakada Kazuto, Hayashi Jun Ichi
Abstract excerpt
This study provided answers to fundamental questions on mammalian mitochondrial genetics: Could respiratory function in mitochondria be maintained by their exchange of genetic contents even when mutations were created within the same genes in different mitochondrial DNA (mtDNA) molecules? Using cell fusion techniques, we created a chance to coexist two types of respiration-deficient syn(-) mitochondria carrying...
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