Article
Interaction theory of mammalian mitochondria.
Biochemical and biophysical research communications - 9 Nov 2001
Nakada K, Inoue K, Hayashi J
Abstract excerpt
We generated mice with deletion mutant mtDNA by its introduction from somatic cells into mouse zygotes. Expressions of disease phenotypes are limited to tissues expressing mitochondrial dysfunction. Considering that all these mice share the same nuclear background, these observations suggest that accumulation of the mutant mtDNA and resultant expressions of mitochondrial dysfunction are responsible for expression...
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