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Article

TAL1/SCL induces leukemia by inhibiting the transcriptional activity of E47/HEB.

Cancer cell - 1 Jun 2004

O'Neil Jennifer, Shank Jennifer, Cusson Nicole, Murre Cornelis, Kelliher Michelle

Abstract excerpt

Activation of the basic-helix-loop-helix (bHLH) gene TAL1 (or SCL) is a frequent gain-of-function mutation in T cell acute lymphoblastic leukemia (T-ALL). To provide genetic evidence that tal1/scl induces leukemia by interfering with E47 and HEB, we expressed tal1/scl in an E2A or HEB heterozygous background. These mice exhibit disease acceleration and perturbed thymocyte development due to repression of E47/HEB...

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Source

Identifiers

PMID: 15193261
DOI: 10.1016/j.ccr.2004.05.023

Genes

TAL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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TAL1/SCL induces leukemia by inhibiting the transcriptional activity of E47/HEB.PMID 15193261Read ↗

Transcriptional regulatory networks downstream of TAL1/SCL in T-cell acute lymphoblastic leukemiaSemantic proximity Read ↗

mSin3A Regulates Murine Erythroleukemia Cell Differentiation through Association with the TAL1 (or SCL) Transcription FactorSemantic proximity Read ↗

Enhancer-Binding Activity of the tal-1 Oncoprotein in Association with the E47/E12 Helix-Loop-Helix ProteinsSemantic proximity Read ↗

Enhancer-binding activity of the tal-1 oncoprotein in association with the E47/E12 helix-loop-helix proteins.Semantic proximity Read ↗

NKX3.1 is a direct TAL1 target gene that mediates proliferation of TAL1-expressing human T cell acute lymphoblastic leukemiaSemantic proximity Read ↗

The TAL1/Scl basic helix-loop-helix protein blocks myogenic differentiation and E-box dependent transactivation.Semantic proximity Read ↗

Transcriptional Regulation of the SCL Locus: Identification of an Enhancer That Targets the Primitive Erythroid Lineage In VivoSemantic proximity Read ↗

Disordered T-Cell Development and T-Cell Malignancies in SCL LMO1 Double-Transgenic Mice: Parallels with E2A-Deficient MiceSemantic proximity Read ↗

A DNA-binding mutant of TAL1 cooperates with LMO2 to cause T cell leukemia in mice.Semantic proximity Read ↗

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Loss of thymocyte competition underlies the tumor suppressive functions of the E2a transcription factor in T lymphocyte acute lymphoblastic leukemiaSemantic proximity Read ↗

An scl gene product lacking the transactivation domain induces bony abnormalities and cooperates with LMO1 to generate T-cell malignancies in transgenic mice.Semantic proximity Read ↗

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