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Article

Isocitrate binding at two functionally distinct sites in yeast NAD+-specific isocitrate dehydrogenase.

The Journal of biological chemistry - 21 Jun 2002

Lin An-Ping, McAlister-Henn Lee

Abstract excerpt

Yeast NAD(+)-specific isocitrate dehydrogenase (IDH) is an octamer containing two types of homologous subunits. Ligand-binding analyses were conducted to examine effects of residue changes in putative catalytic and regulatory isocitrate-binding sites respectively contained in IDH2 and IDH1 subunits. Replacement of homologous serine residues in either subunit site, S98A in IDH2 or S92A in IDH1, was found to reduce...

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Source

Identifiers

PMID: 11953438
DOI: 10.1074/jbc.M202534200

Genes

IDH1
IDH2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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