Article
The MTHFR 1298CC and 677TT genotypes have opposite associations with red cell folate levels.
Molecular genetics and metabolism - 1 Jul 2006
Parle-McDermott Anne, Mills James L, Molloy Anne M, Carroll Nicola, Kirke Peadar N, Cox Christopher, Conley Mary R, Pangilinan Faith J, Brody Lawrence C, Scott John M
Abstract excerpt
Individuals homozygous for the thermolabile variant (677TT) of methylenetetrahydrofolate reductase exhibit reduced folate status as evidenced by a drop in the biomarker red cell folate (RCF) compared to those who carry at least one 677C allele. We now report that a different polymorphism in the same enzyme, namely 1298A>C, is associated with increased RCF levels. Thus, these two common polymorphisms change a...
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