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Article

Deciphering the folate puzzle: Unraveling the impact of genetic variations and metabolites on cancer risk.

International journal of cancer - 1 Oct 2024

Liu Tong, Liu Chen-An, Wei Ya-Ping, Song Meng-Meng, Zhang Qi, Song Yun, Chen Ping, Liu Li-Shun, Wang Bin-Yan, Shi Han-Ping

Abstract excerpt

The C677T polymorphism in the MTHFR gene and its role in folate metabolism, impacting serum folate metabolites like THF and 5-MTHF, is a critical but underexplored area in cancer research. This nested case-control study utilized data from CHHRS, involving 87,492 hypertensive adults without prior cancer. During a median of 2.02 years, we identified 1332 cancer cases and matched controls based on age, sex, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38783579
DOI: 10.1002/ijc.35043

Genes

MTHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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Deciphering the folate puzzle: Unraveling the impact of genetic variations and metabolites on cancer risk.PMID 38783579Read ↗

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