Article
Thermolabile variant of 5,10-methylenetetrahydrofolate reductase associated with low red-cell folates: implications for folate intake recommendations.
Lancet (London, England) - 31 May 1997
Molloy A M, Daly S, Mills J L, Kirke P N, Whitehead A S, Ramsbottom D, Conley M R, Weir D G, Scott J M
Abstract excerpt
BACKGROUND: The dietary reference values for folate, as for other nutrients, are targeted to the general and supposedly normal population, not people with special needs, such as those with genetic or metabolic abnormalities or diseases. However, 5-15% of general populations are homozygous for a thermolabile variant of 5,10-methylenetetrahydrofolate reductase (C677T) which causes mild hyperhomocysteinaemia and is...
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