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D-loop mutations in mitochondrial DNA are a risk factor for chemotherapy resistance in esophageal cancer.

Scientific reports - 30 Dec 2024

Harino Takashi, Tanaka Koji, Motooka Daisuke, Masuike Yasunori, Takahashi Tsuyoshi, Yamashita Kotaro, Saito Takuro, Yamamoto Kazuyoshi, Makino Tomoki, Kurokawa Yukinori, Nakajima Kiyokazu, Eguchi Hidetoshi, Doki Yuichiro

Abstract excerpt

Esophageal cancer is a highly aggressive disease, and acquired resistance to chemotherapy remains a significant hurdle in its treatment. mtDNA, crucial for cellular energy production, is prone to mutations at a higher rate than nuclear DNA. These mutations can accumulate and disrupt cellular function; however, mtDNA mutations induced by chemotherapy in esophageal cancer remain unexplored. We aimed to identify...

Topics

Humans
DNA, Mitochondrial
Esophageal Neoplasms
Drug Resistance, Neoplasm
Mutation
Male
Cell Line, Tumor
Female
Middle Aged
Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Risk Factors

Esophageal Squamous Cell Carcinoma

Source

Open in PubMed Open full text

Identifiers

PMID: 39738117
DOI: 10.1038/s41598-024-80226-3
PMCID: PMC11685473

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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