Article
Identification of a sudden cardiac death susceptibility locus at 2q24.2 through genome-wide association in European ancestry individuals.
PLoS genetics - 1 Jun 2011
Arking Dan E, Junttila M Juhani, Goyette Philippe, Huertas-Vazquez Adriana, Eijgelsheim Mark, Blom Marieke T, Newton-Cheh Christopher, Reinier Kyndaron, Teodorescu Carmen, Uy-Evanado Audrey, Carter-Monroe Naima, Kaikkonen Kari S, Kortelainen Marja-Leena, Boucher Gabrielle, Lagacé Caroline, Moes Anna, Zhao XiaoQing, Kolodgie Frank, Rivadeneira Fernando, Hofman Albert, Witteman Jacqueline C M, Uitterlinden André G, Marsman Roos F, Pazoki Raha, Bardai Abdennasser, Koster Rudolph W, Dehghan Abbas, Hwang Shih-Jen, Bhatnagar Pallav, Post Wendy, Hilton Gina, Prineas Ronald J, Li Man, Köttgen Anna, Ehret Georg, Boerwinkle Eric, Coresh Josef, Kao W H Linda, Psaty Bruce M, Tomaselli Gordon F, Sotoodehnia Nona, Siscovick David S, Burke Greg L, Marbán Eduardo, Spooner Peter M, Cupples L Adrienne, Jui Jonathan, Gunson Karen, Kesäniemi Y Antero, Wilde Arthur A M, Tardif Jean-Claude, O'Donnell Christopher J, Bezzina Connie R, Virmani Renu, Stricker Bruno H C H, Tan Hanno L, Albert Christine M, Chakravarti Aravinda, Rioux John D, Huikuri Heikki V, Chugh Sumeet S
Abstract excerpt
Sudden cardiac death (SCD) continues to be one of the leading causes of mortality worldwide, with an annual incidence estimated at 250,000-300,000 in the United States and with the vast majority occurring in the setting of coronary disease. We performed a genome-wide association meta-analysis in 1,283 SCD cases and >20,000 control individuals of European ancestry from 5 studies, with follow-up genotyping in up to...
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