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Article

Induction of Gsk3β-β-TrCP interaction is required for late phase stabilization of β-catenin in canonical Wnt signaling.

The Journal of biological chemistry - 7 Mar 2014

Gao Chenxi, Chen Guangming, Romero Guillermo, Moschos Stergios, Xu Xiang, Hu Jing

Abstract excerpt

A pivotal step in canonical Wnt signaling is Wnt-induced β-catenin stabilization. In the absence of Wnt, β-catenin is targeted for β-transducin repeats-containing proteins (β-TrCP)-mediated degradation due to phosphorylation by glycogen synthase kinase 3 (Gsk3). How canonical Wnt signaling regulates Gsk3 to inhibit β-catenin proteolysis remains largely elusive. This study reveals novel key molecular events in Wnt...

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Source

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Identifiers

PMID: 24451375
DOI: 10.1074/jbc.M113.532606
PMCID: PMC3945370

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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