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Article

Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development.

Proceedings of the National Academy of Sciences of the United States of America - 25 Apr 2006

Gavin Marc A, Torgerson Troy R, Houston Evan, DeRoos Paul, Ho William Y, Stray-Pedersen Asbjørg, Ocheltree Elizabeth L, Greenberg Philip D, Ochs Hans D, Rudensky Alexander Y

Abstract excerpt

Forkhead winged-helix transcription factor Foxp3 serves as the dedicated mediator of the genetic program governing CD25+CD4+ regulatory T cell (T(R)) development and function in mice. In humans, its role in mediating T(R) development has been controversial. Furthermore, the fate of T(R) precursors in FOXP3 deficiency has yet to be described. Making use of flow cytometric detection of human FOXP3, we have...

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Identifiers

PMID: 16617117
DOI: 10.1073/pnas.0509484103
PMCID: PMC1458937

Genes

FOXP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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