Article
Wild-type FOXP3 is selectively active in CD4+CD25(hi) regulatory T cells of healthy female carriers of different FOXP3 mutations.
Blood - 5 Nov 2009
Di Nunzio Sara, Cecconi Massimiliano, Passerini Laura, McMurchy Alicia N, Baron Udo, Turbachova Ivana, Vignola Silvia, Valencic Erica, Tommasini Alberto, Junker Anne, Cazzola Giantonio, Olek Sven, Levings Megan K, Perroni Lucia, Roncarolo Maria Grazia, Bacchetta Rosa
Abstract excerpt
Forkhead box P3 (FOXP3) is constitutively expressed by CD4(+)CD25(hi) regulatory T cells (nTregs). Mutations of FOXP3 cause a severe autoimmune syndrome known as immune dysregulation polyendocrinopathy enteropathy X-linked, in which nTregs are absent or dysfunctional. Whether FOXP3 is essential for both differentiation and function of human nTreg cells remains to be demonstrated. Because FOXP3 is an X-linked gene...
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