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Article

CD25 deficiency causes an immune dysregulation, polyendocrinopathy, enteropathy, X-linked-like syndrome, and defective IL-10 expression from CD4 lymphocytes.

The Journal of allergy and clinical immunology - 1 Feb 2007

Caudy Amy A, Reddy Sreelatha T, Chatila Talal, Atkinson John P, Verbsky James W

Abstract excerpt

BACKGROUND: Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) results in systemic autoimmunity from birth and can be caused by mutations in the transcription factor forkhead box P3 (FOXP3). OBJECTIVE: To determine if Foxp3 is required for the generation of IL-10-expressing T regulatory cells. METHODS: CD4 lymphocytes were isolated from patients with IPEX-like syndromes and activated with...

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Source

Identifiers

PMID: 17196245
DOI: 10.1016/j.jaci.2006.10.007

Genes

FOXP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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