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Article

IPEX and the role of Foxp3 in the development and function of human Tregs.

The Journal of clinical investigation - 1 Jun 2006

Le Bras Séverine, Geha Raif S

Abstract excerpt

Genetic defects in the transcription factor forkhead box protein P3 (Foxp3) cause immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX). IPEX is thought to be due to a defect in naturally arising CD4+ Tregs. In this issue of the JCI, Bacchetta and colleagues demonstrate that patients with IPEX and missense mutations in Foxp3 provide insight into the role of various domains of Foxp3 in the...

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Share to CD4-Positive T-Lymphocytes
Share to Forkhead Transcription Factors
Share to Genetic Diseases, X-Linked

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation, Missense

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Share to Polyendocrinopathies, Autoimmune

Share to T-Lymphocytes, Regulatory

Source

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Identifiers

PMID: 16741571
DOI: 10.1172/JCI28880
PMCID: PMC1464917

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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