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Article

Small protein B interacts with the large and the small subunits of a stalled ribosome during trans-translation.

Nucleic acids research - 1 Jan 2006

Hallier Marc, Desreac Jessie, Felden Brice

Abstract excerpt

During trans-translation, stalled bacterial ribosomes are rescued by small protein B (SmpB) and by transfer-messenger RNA (tmRNA). Stalled ribosomes switch translation from the defective messages to a short internal reading frame on tmRNA that tags the nascent peptide chain for degradation and recycles the ribosomes. We present evidences that SmpB binds the large and small ribosomal subunits in vivo and in vitro....

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Identifiers

PMID: 16611927
DOI: 10.1093/nar/gkl097
PMCID: PMC1435831

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Small protein B interacts with the large and the small subunits of a stalled ribosome during trans-translation.PMID 16611927Read ↗

Pre-binding of small protein B to a stalled ribosome triggers trans-translation.Semantic proximity Read ↗

A previously uncharacterized role for small protein B (SmpB) in transfer messenger RNA-mediated trans-translation.Semantic proximity Read ↗

Ribosomal protein S1 influences trans-translation in vitro and in vivo.Semantic proximity Read ↗

SmpB contributes to reading frame selection in the translation of transfer-messenger RNA.Semantic proximity Read ↗

SmpB functions in various steps of trans-translation.Semantic proximity Read ↗

Function of the SmpB tail in transfer-messenger RNA translation revealed by a nucleus-encoded form.Semantic proximity Read ↗

Ribosomal protein S1 binds mRNA and tmRNA similarly but plays distinct roles in translation of these molecules.Semantic proximity Read ↗

In vitro trans-translation of Thermus thermophilus: ribosomal protein S1 is not required for the early stage of trans-translation.Semantic proximity Read ↗

rRNA mutations that inhibit transfer-messenger RNA activity on stalled ribosomes.Semantic proximity Read ↗

A functional interaction of SmpB with tmRNA for determination of the resuming point of trans-translation.Semantic proximity Read ↗

A novel GTPase activated by the small subunit of ribosome.Semantic proximity Read ↗

Requirements for resuming translation in chimeric transfer-messenger RNAs of Escherichia coli and Mycobacterium tuberculosis.Semantic proximity Read ↗

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