Article
Ribosomal protein S1 binds mRNA and tmRNA similarly but plays distinct roles in translation of these molecules.
Proceedings of the National Academy of Sciences of the United States of America - 14 Sept 2004
McGinness Kathleen E, Sauer Robert T
Abstract excerpt
Ribosomes stalled during protein synthesis can be rescued by tmRNA, which acts first as a tRNA and then as an mRNA to direct addition of a C-terminal degradation tag to the nascent polypeptide. Ribosomal protein S1 binds tmRNA, but its functional role in tmRNA-mediated tagging is uncertain. To probe interactions between S1 and tmRNA, truncated variants missing one or more of the six contiguous S1 domains were...
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