Article
Platelet-derived growth factor receptor sequences important for binding of src family tyrosine kinases.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Oct 1991
Courtneidge S A, Kypta R M, Cooper J A, Kazlauskas A
Abstract excerpt
We previously demonstrated that src family tyrosine kinases associate with activated platelet-derived growth factor receptors. We have now investigated the requirement for tyrosine phosphorylation sites in the human platelet-derived growth factor receptor for this binding. Tyrosine 857, but not tyrosine 751, is required for efficient association. Furthermore, even though src family tyrosine kinases associate with...
Topics
- Animals
- Binding Sites
- Blotting, Western
- Cells, Cultured
- Culture Media, Serum-Free
- Dogs
- Genes, src
- Mutation
- Phosphorylation
- Protein Binding
- Protein-Tyrosine Kinases