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Article

Polymorphism in the proximal promoter region of the perforin gene and its impact on the course of HIV infection.

International journal of immunogenetics - 1 Apr 2006

McIlroy D, Meyer L, Dudoit Y, Samri A, Delfraissy J-F, Autran B, Debré P, Theodorou I

Abstract excerpt

Cytotoxic T lymphocytes (CTLs) play an essential role in the control of viral replication during human immunodeficiency virus (HIV) infection. However, the efficacy of the CTL response varies between individuals. We tested the hypothesis that genetic polymorphisms in the lytic effector molecule perforin could influence the progression of HIV infection. The perforin gene was screened for single nucleotide...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16611250
DOI: 10.1111/j.1744-313X.2006.00571.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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