Article
Study of p53 codon 72 polymorphism in patients with breast cancer.
European journal of gynaecological oncology - 1 Jan 2008
Vieira J O, da Silva I D C G, Higo P E S, Nogueira-de-Souza N C, Gebrim L H
Abstract excerpt
Breast cancer is a common disease in Western societies, with an incidence of 46.31/100,000 women/year in Brazil. The tumor suppressor gene TP53 is one of the most studied genes regarding the presence of mutations. Indeed, 50% of all tumors are known to exhibit changes in the TP53 nucleotide sequence due to carcinogenic processes. As to the presence of polymorphism, the TP53 gene is polymorphic at the nucleotide...
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