Article
HLA-DQB1*0305 and -DQB1*0304 alleles among Sardinians. Evolutionary and practical implications for oligotyping.
Human immunology - 1 Jun 1994
Cucca F, Frau F, Lampis R, Floris M, Argiolas L, Macis D, Cao A, De Virgiliis S, Congia M
Abstract excerpt
This study, performed in individuals of Sardinian descent, reports an epidemiologic and molecular analysis of the recently identified DQB1*0304 and DQB1*0305 alleles. These two alleles having a gene frequency of 0.017 and 0.005, respectively, are not uncommon in Sardinia and are distributed fairly uniformly on the island. The analysis of DQB1 second and third exons of the two alleles revealed that although they...
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