Article
The inter-regional distribution of HLA class II haplotypes indicates the suitability of the Sardinian population for case-control association studies in complex diseases.
Human molecular genetics - 12 Dec 2000
Lampis R, Morelli L, Congia M, Macis M D, Mulargia A, Loddo M, De Virgiliis S, Marrosu M G, Todd J A, Cucca F
Abstract excerpt
We have analysed HLA class II gene-based substructure of the Sardinian population in order to evaluate the possible influence of this parameter in the mapping of common disease loci using association methods. We first examined the distribution of the HLA-DRB1-DQA1-DQB1 haplotypes in 631 newborns from seven different regions of the island, and found that the most frequent haplotypes were uniformly distributed in...
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