Article
The HLA DQB1*0502 allele is neutrally associated with insulin-dependent diabetes mellitus in the Sardinian population.
Tissue antigens - 1 May 1992
Muntoni F, Congia M, Cucca F, Cossu P, Porcu S, Frau F, Arnone M, Songini M, Muntoni S, Cao A
Abstract excerpt
In the Sardinian population a very high incidence of insulin-dependent diabetes mellitus (IDDM) and the lack of HLA-DR2 protective effect due to the high frequency of the A2, Cw7, B17, 3F31, DR2, DQw1 extended haplotype has been reported. This haplotype, carrying a Serine at position 57 of the DQB1*0502 allele, has been previously reported to be underrepresented in patients when compared to controls. In order to...
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