The HLA DQB1*0502 allele is neutrally associated with insulin-dependent diabetes mellitus in the Sardinian population.

doi:10.1111/j.1399-0039.1992.tb01945.x

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Article

The HLA DQB1*0502 allele is neutrally associated with insulin-dependent diabetes mellitus in the Sardinian population.

Tissue antigens - 1 May 1992

Muntoni F, Congia M, Cucca F, Cossu P, Porcu S, Frau F, Arnone M, Songini M, Muntoni S, Cao A

Abstract excerpt

In the Sardinian population a very high incidence of insulin-dependent diabetes mellitus (IDDM) and the lack of HLA-DR2 protective effect due to the high frequency of the A2, Cw7, B17, 3F31, DR2, DQw1 extended haplotype has been reported. This haplotype, carrying a Serine at position 57 of the DQ...

Topics

Adolescent
Adult
Alleles
Autoimmune Diseases
Base Sequence
Diabetes Mellitus, Type 1
Disease Susceptibility
Female
Gene Frequency
Genes, MHC Class II
Genetic Predisposition to Disease
HLA-DQ Antigens
HLA-DQ beta-Chains
Heterozygote
Humans
Italy
Male
Middle Aged

Source

Open in PubMed

Identifiers

PMID: 1412411
DOI: 10.1111/j.1399-0039.1992.tb01945.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1412411-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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