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Article

Inhibitory antibodies to human angiotensin-converting enzyme: fine epitope mapping and mechanism of action.

Biochemistry - 18 Apr 2006

Skirgello Olga E, Balyasnikova Irina V, Binevski Petr V, Sun Zhu-Li, Baskin Igor I, Palyulin Vladimir A, Nesterovitch Andrei B, Albrecht Ronald F, Kost Olga A, Danilov Sergei M

Abstract excerpt

Angiotensin I-converting enzyme (ACE), a key enzyme in cardiovascular pathophysiology, consists of two homologous domains (N and C), each bearing a Zn-dependent active site. We modeled the 3D-structure of the ACE N-domain using known structures of the C-domain of human ACE and the ACE homologue, ACE2, as templates. Two monoclonal antibodies (mAb), 3A5 and i2H5, developed against the human N-domain of ACE,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16605251
DOI: 10.1021/bi052591h

Genes

ACE
ACE2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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