Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cardiac troponin I: a case study in rational antibody design for human diagnostics.

Protein engineering, design & selection : PEDS - 1 Jun 2012

Conroy P J, O'Kennedy R J, Hearty S

Abstract excerpt

In vitro diagnostic (IVD) platforms provide rapid and accurate determination of disease status. The clinical performance of antibody-based diagnostic platforms is paramount as the information provided often informs the medical intervention taken and, ultimately, the patient's outcome. Breaking down such an immuno-IVD device into its component elements, the biorecognition entity is key to the analytical...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adjuvants, Immunologic
Share to Chickens
Share to High-Throughput Screening Assays

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hybridomas

Share to Peptide Library

Share to Single-Chain Antibodies

Share to Surface Plasmon Resonance

Share to Troponin I

Source

Identifiers

PMID: 22509048
DOI: 10.1093/protein/gzs018

Genes

IVD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cardiac troponin I: a case study in rational antibody design for human diagnostics.PMID 22509048Read ↗

Drug-like antibodies with high affinity, diversity and developability directly from next-generation antibody librariesSemantic proximity Read ↗

Beyond antibodies: using biological principles to guide the development of next-generation protein therapeuticsSemantic proximity Read ↗

Atomically accurate de novo design of antibodies with RFdiffusionSemantic proximity Read ↗

Dual-Specific Antibody Design Using Artificial IntelligenceSemantic proximity Read ↗

ALTHEA Gold Libraries™: antibody libraries for therapeutic antibody discoverySemantic proximity Read ↗

General strategy for the generation of human antibody variable domains with increased aggregation resistance.Semantic proximity Read ↗

Designing Human Antibodies by Phage DisplaySemantic proximity Read ↗

Design and Use of a Phage Display LibrarySemantic proximity Read ↗

Generation and analyses of human synthetic antibody libraries and their application for protein microarraysSemantic proximity Read ↗

An integrated in silico-in vitro workflow for discovering high-affinity, selective antibodies to the KRAS(G12D)-MHC I complexSemantic proximity Read ↗

Aptamers: An Emerging Class of Molecules That Rival Antibodies in DiagnosticsSemantic proximity Read ↗

A structure-based engineering approach to abrogate pre-existing antibody binding to biotherapeuticsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.