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Article

Clinical significance of aflatoxin, mutant P53 gene and sIL-2 receptor in liver cirrhosis and hepatocellular carcinoma.

Journal of the Egyptian Society of Parasitology - 1 Apr 2006

El-Shanawani Faten M, Abdel-Hadi Afaf A, Abu Zikri Nadia B, Ismail Alaa, El-Ansary Mahmoud, El-Raai Ahmed

Abstract excerpt

The incidence of hepatocellular carcinoma (HCC) varies widely worldwide. Chronic infection with hepatitis B virus (HBV) and exposure to aflatoxins in foodstuffs are the main risk factors. AAG to AGT transversion at codon 249 of the P53 gene arg-ser (249ser) has been identified as a hotspot, reflecting DNA damage caused by aflatoxin B1 metabolites in HCC. Because HBV infection is often endemic in high aflatoxin...

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Share to Aflatoxin B1
Share to Carcinoma, Hepatocellular

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Mutational Analysis

Share to Genes, p53

Share to Hepatitis B, Chronic

Share to Liver Cirrhosis

Share to Liver Neoplasms

Share to Receptors, Interleukin-2

Source

Identifiers

PMID: 16605112

Genes

AGT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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