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Article

Hepatocellular carcinoma and the underlying mechanisms.

African health sciences - 1 Mar 2010

Oyagbemi A A, Azeez O I, Saba A B

Abstract excerpt

The incidence of hepatocellular carcinoma is increasing worldwide as well as the associated risk factors, some of which include exposure to aflatoxin B1, Hepatitis B (HBV) virus and hepatitis C (HCV) virus. Mutation of tumour suppressor gene p53 at codon 249(ser) at exon 7 has been found to contribute significantly to replication of damaged DNA and subsequent tumour progression. The x gene of HBV (HBx) is the...

Topics

Aflatoxin B1
Carcinoma, Hepatocellular
DNA Repair
Hepacivirus
Hepatitis B
Hepatitis B virus
Hepatitis C
Humans
Incidence
Liver Neoplasms
Mutation
Risk Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Trans-Activators

Tumor Suppressor Protein p53

Viral Regulatory and Accessory Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 20811532
PMCID: PMC2895801

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-20811532-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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