Article
Dominant role of hepatitis B virus and cofactor role of aflatoxin in hepatocarcinogenesis in Qidong, China.
Hepatology (Baltimore, Md.) - 1 Nov 2002
Ming Lihua, Thorgeirsson Snorri S, Gail Mitchell H, Lu Peixin, Harris Curtis C, Wang Nengjin, Shao Yongfu, Wu Zhiyuan, Liu Guoting, Wang Xiaohong, Sun Zongtang
Abstract excerpt
We assessed the separate and combined effects of hepatitis B virus (HBV), hepatitis C virus (HCV), and aflatoxin in causing hepatocellular carcinoma (HCC) in Qidong, China. A consecutive series of 181 pathologic-diagnosed HCC cases were studied for hepatitis B surface antigen (HBsAg), anti-HBc, HBV X gene sequence, anti-HCV, the 249ser-p53 mutation, and chronic hepatitis pathology. Each of the 181 incident HCC...
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