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Article

Control of histone H3 lysine 9 (H3K9) methylation state via cooperative two-step demethylation by Jumonji domain containing 1A (JMJD1A) homodimer.

The Journal of biological chemistry - 27 Dec 2013

Goda Satoshi, Isagawa Takayuki, Chikaoka Yoko, Kawamura Takeshi, Aburatani Hiroyuki

Abstract excerpt

Post-translational histone methylation is a dynamic and reversible process that is involved in the spatio-temporal regulation of gene transcription and contributes to various cellular phenotypes. Methylation of histone H3 at lysine 9 (H3K9), which is generally a transcriptional repression mark, is demethylated by H3K9-specific demethylases, leading to transcriptional activation. However, how multiple demethylases...

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Identifiers

PMID: 24214985
DOI: 10.1074/jbc.M113.492595
PMCID: PMC3873553

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