Article
Evidence for involvement of superantigens in human periodontal diseases: skewed expression of T cell receptor variable regions by gingival T cells.
Oral microbiology and immunology - 1 Apr 1996
Zadeh H H, Kreutzer D L
Abstract excerpt
Immunomodulation by periodontopathic bacteria has been implicated in the pathogenesis of inflammatory periodontal diseases. A novel class of microbial-derived T cell mitogens, referred to as superantigens, has recently been described. Superantigens are unique in that they induce a tremendous acti...
Topics
- Adult
- Antibodies, Monoclonal
- Antibody Specificity
- Antigens, Bacterial
- B-Lymphocytes
- Female
- Gingiva
- Humans
- Lymphocyte Activation
- Male
- Middle Aged
- Periodontitis
- Phenotype
- Receptors, Antigen, T-Cell, alpha-beta
- Superantigens
- T-Lymphocytes