Article
Abnormal DNA end-joining activity in human head and neck cancer.
International journal of molecular medicine - 1 May 2006
Shin Ki-Hyuk, Kang Mo K, Kim Reuben H, Kameta Ayako, Baluda Marcel A, Park No-Hee
Abstract excerpt
In human cells, DNA double-strand breaks (DSBs) are repaired primarily by the DNA end-joining (EJ) process and thus, abnormal DNA EJ activities lead to an accumulation of mutations and/or aneuploidy, resulting in genetic instability of cells. Since genetic instability is the hallmark of cancer cells, we studied the DNA EJ activities of normal, non-malignant immortalized and malignant human epithelial cells to...
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