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Human papillomavirus 16 promotes microhomology-mediated end-joining

7 Oct 2019

Abstract excerpt

Squamous cell carcinomas (SCCs) arising from aerodigestive or anogenital epithelium that are associated with the human papillomavirus (HPV) are far more readily cured with radiation therapy than HPV-negative SCCs. The mechanism behind this increased radiosensitivity has been proposed to be secondary to defects in DNA repair, although the specific repair pathways that are disrupted have not been elucidated. To...

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PMID: 31591214
DOI: 10.1073/pnas.1906120116

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