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Article

Imprecision and DNA Break Repair Biased towards Incompatible End Joining in Leukemia

8 Dec 2017

Abstract excerpt

Abstract Cancer is a genetic disease caused by mutations and chromosomal abnormalities that contribute to uncontrolled cell growth. In addition, cancer cells can rapidly respond to conventional and targeted therapies by accumulating novel and often specific genetic lesions leading to acquired drug resistance and relapsing disease. In chronic lymphocytic leukemia (CLL), however, diverse chromosomal aberrations...

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PMID: 29222170
DOI: 10.1158/1541-7786.mcr-17-0373

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