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DNA double strand break repair in human bladder cancer is error prone and involves microhomology-associated end-joining

23 Sept 2004

Abstract excerpt

In human cells DNA double strand breaks (DSBs) can be repaired by the non-homologous end-joining (NHEJ) pathway. In a background of NHEJ deficiency, DSBs with mismatched ends can be joined by an error-prone mechanism involving joining between regions of nucleotide microhomology. The majority of joins formed from a DSB with partially incompatible 3' overhangs by cell-free extracts from human glioblastoma (MO59K)...

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PMID: 15466592
DOI: 10.1093/nar/gkh842

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