Effect of metabotropic glutamate receptor 3 genotype on N-acetylaspartate measures in the dorsolateral prefrontal cortex.

doi:10.1176/ajp.2006.163.4.740

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Effect of metabotropic glutamate receptor 3 genotype on N-acetylaspartate measures in the dorsolateral prefrontal cortex.

The American journal of psychiatry - 1 Apr 2006

Marenco Stefano, Steele Sonya U, Egan Michael F, Goldberg Terry E, Straub Richard E, Sharrief Anjail Z, Weinberger Daniel R

Abstract excerpt

OBJECTIVE: This study was carried out to confirm prior evidence of an effect of a single nucleotide polymorphism (SNP) in the metabotropic glutamate receptor 3 (GRM3) gene (a putative risk factor for schizophrenia) on measures of N-acetylaspartate in healthy comparison subjects. METHOD: Fifty-four carefully screened healthy volunteers genotyped at SNP rs6465084 underwent magnetic resonance spectroscopic imaging...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aspartic Acid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Creatine

Share to Functional Laterality

Share to Magnetic Resonance Spectroscopy

Share to Neuropsychological Tests

Share to Prefrontal Cortex

Share to Psychiatric Status Rating Scales

Share to Receptors, Metabotropic Glutamate

Source

Open in PubMed Open full text

Identifiers

PMID: 16585454
DOI: 10.1176/ajp.2006.163.4.740
PMCID: PMC1855226

Genes

GRM3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effect of metabotropic glutamate receptor 3 genotype on N-acetylaspartate measures in the dorsolateral prefrontal cortex.PMID 16585454Read ↗

Variation in GRM3 affects cognition, prefrontal glutamate, and risk for schizophrenia.Semantic proximity Read ↗

Effect of metabotropic glutamate receptor 3 genotype on N-acetylaspartate levels and neurocognition in non-smoking, active alcoholics.Semantic proximity Read ↗

Effect of metabotropic glutamate receptor-3 variants on prefrontal brain activity in schizophrenia: An imaging genetics study using multi-channel near-infrared spectroscopy.Semantic proximity Read ↗

Association between the polymorphic GRM3 gene and negative symptom improvement during olanzapine treatment.Semantic proximity Read ↗

Effects of neuregulin 3 genotype on human prefrontal cortex physiology.Semantic proximity Read ↗

Further evidence for a functional role of the glutamate receptor gene GRM3 in schizophrenia.Semantic proximity Read ↗

Expression of a GRM3 splice variant is increased in the dorsolateral prefrontal cortex of individuals carrying a schizophrenia risk SNP.Semantic proximity Read ↗

Pharmacogenetic associations of the type-3 metabotropic glutamate receptor (GRM3) gene with working memory and clinical symptom response to antipsychotics in first-episode schizophrenia.Semantic proximity Read ↗

Association of GRM3 polymorphism with white matter integrity in schizophrenia.Semantic proximity Read ↗

Elevated 3T proton MRS glutamate levels associated with poor Continuous Performance Test (CPT-0X) scores and genetic risk for schizophrenia.Semantic proximity Read ↗

Genetic variations of the NR3A subunit of the NMDA receptor modulate prefrontal cerebral activity in humans.Semantic proximity Read ↗

Altered effect of dopamine transporter 3'UTR VNTR genotype on prefrontal and striatal function in schizophrenia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.