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Article

Frequent Met Oncogene Amplification in a Brca1/Trp53 Mouse Model of Mammary Tumorigenesis

1 Apr 2006

Abstract excerpt

In a screen for gene copy number alterations in mouse mammary tumors initiated by loss of the Brca1 and Trp53 genes, we observed that the majority (11 of 15; 73%) had high-level amplification of wild-type Met, encoding a growth factor receptor implicated in tumor progression. Met amplification was localized to unstable double minute chromosomes and was uniquely found in mouse breast tumors driven by loss of Brca1...

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PMID: 16585167
DOI: 10.1158/0008-5472.can-05-4181

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Frequent Met Oncogene Amplification in a Brca1/Trp53 Mouse Model of Mammary TumorigenesisPMID 16585167Read ↗

A mouse model of activating Met mutations.Semantic proximity Read ↗

Mammary tumors in mice conditionally mutant for Brca1 exhibit gross genomic instability and centrosome amplification yet display a recurring distribution of genomic imbalances that is similar to human breast cancer.Semantic proximity Read ↗

Somatic Trp53 mutations differentially drive breast cancer and evolution of metastasesSemantic proximity Read ↗

Met synergizes with p53 loss to induce mammary tumors that possess features of claudin-low breast cancerSemantic proximity Read ↗

Profiling YB-1 target genes uncovers a new mechanism for MET receptor regulation in normal and malignant human mammary cellsSemantic proximity Read ↗

Copy Number Aberrations in Mouse Breast Tumors Reveal Loci and Genes Important in Tumorigenic Receptor Tyrosine Kinase SignalingSemantic proximity Read ↗

Aberrations of c-MET drive breast cancer metastasis in an HGF-dominant environmentSemantic proximity Read ↗

Multiple genetic changes are associated with mammary tumorigenesis in Brca1 conditional knockout mice.Semantic proximity Read ↗

Lack of major genome instability in tumors of p53 null rats.Semantic proximity Read ↗

Activating Met mutations produce unique tumor profiles in mice with selective duplication of the mutant allele.Semantic proximity Read ↗

Gain of function in the mouse model of a recurrent mutation p53N236S promotes the formation of double minute chromosomes and the oncogenic potential of p19ARF.Semantic proximity Read ↗

MET and MYC cooperate in mammary tumorigenesis.Semantic proximity Read ↗

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